Abstract
Pyridazin-3(2H)-ones are inexpensive, stable, and easily prepared heterocycles. Since pyridazin-3(2H)-ones readily form stable anions, and can act as good leaving group. Their utility as synthetic auxiliaries was recently demonstrated by Yoon’s group. 2- Substituted-pyridazin-3(2H)-ones are also useful both the electrophilic agents and equivalents for the functionalization of the electron rich compounds and active methylenes, and synthones. 2-Substituted-pyridazin-3(2H)-ones are novel green agents because that can be recovered quantitatively and recycled. In this review, the preparation and the synthetic application of 2-substituted-pyridazin-3(2H)-ones are described.
Keywords: Acylation, Cyanation, Electrophilic halogenation, N-nitration, Coupling agent, Lactonization, N-arylsulfonation, 2-substitutedpyridazin- 3(2H)-one.
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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