Pharmacokinetics and Disposition of Nanomedicine Using Biodegradable PEG/PCL Polymers as Drug Carriers

Title:Pharmacokinetics and Disposition of Nanomedicine Using Biodegradable PEG/PCL Polymers as Drug Carriers

Volume: 13 Issue: 4

Author(s): YuJun Wang, MaLing Gou, ChangYang Gong, Cheng Wang, ZhiYong Qian, Yun Feng Lin and Feng Luo

Affiliation:

Keywords: PEG, PCL, micelles, biodegradation, release, long circulation, target

Abstract: Micelles assembled from amphiphilic poly(ethylene glycol)/poly(ε -caprolactone) (PEG/PCL) copolymers are promised as safe and effective drug delivery systems. They offer the potential to achieve high solubility of hydrophobic drugs, long blood circulation time and effective delivery to target organs. These advantages contribute to their application as vehicles of a broad variation of therapeutic compounds. In this review, we discussed the safety of the copolymers, release behavior of PEG/PCL micelles in vitro, and pharmacokinetic profiles referring to the optimized fate in vascular system and targeting biodistribution.

Cite this article as:

Wang YuJun, Gou MaLing, Gong ChangYang, Wang Cheng, Qian ZhiYong, Feng Lin Yun and Luo Feng, Pharmacokinetics and Disposition of Nanomedicine Using Biodegradable PEG/PCL Polymers as Drug Carriers, Current Drug Metabolism 2012; 13 (4) . https://dx.doi.org/10.2174/138920012800166490