Luminescent G-quadruplex Probes

Dik-Lung      Ma; Daniel      Shiu-Hin Chan; Hui      Yang; Hong-Zhang      He; Chung-Hang      Leung

doi:10.2174/138161212799958314

Abstract

G-quadruplexes have found increasing potential in applications such as molecular therapeutics, diagnostics, and sensing. As a consequence, small molecules capable of selectively detecting G-quadruplexes have received significant attention in recent literature. Our review here addresses representative advances in the development of luminescent G-quadruplex probes and highlights their potential applications in sensing and imaging.

Keywords: G-quadruplex, DNA, small molecules, luminescent probes, detection, diagnostics, telomere, topologies, propeller, emission

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Current Pharmaceutical Design

Title:Luminescent G-quadruplex Probes

Volume: 18 Issue: 14

Author(s): Dik-Lung Ma, Daniel Shiu-Hin Chan, Hui Yang, Hong-Zhang He and Chung-Hang Leung

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Keywords: G-quadruplex, DNA, small molecules, luminescent probes, detection, diagnostics, telomere, topologies, propeller, emission

Abstract: G-quadruplexes have found increasing potential in applications such as molecular therapeutics, diagnostics, and sensing. As a consequence, small molecules capable of selectively detecting G-quadruplexes have received significant attention in recent literature. Our review here addresses representative advances in the development of luminescent G-quadruplex probes and highlights their potential applications in sensing and imaging.

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Ma Dik-Lung, Shiu-Hin Chan Daniel, Yang Hui, He Hong-Zhang and Leung Chung-Hang, Luminescent G-quadruplex Probes, Current Pharmaceutical Design 2012; 18 (14) . https://dx.doi.org/10.2174/138161212799958314