Abstract
Extracellular signaling molecules have been implicated in the progression of Retinal Degeneration (RD). Gene regulatory events linked to the maintenance of retinal structure and function incorporate signaling cascades that may serve as therapeutic targets for some forms of blindness. This review shall focus on the evidence for non-cell-autonomous mechanisms that affect the pattern of degeneration seen in retinal dystrophies, the types of signals that may influence the course of degeneration and finally with the related prospects for retinal-therapies.
Keywords: Signaling, photoreceptor, neuroprotection, retinal degeneration, trophic factors, thioredoxin
Current Gene Therapy
Title: Retinal Degenerations: From Cell Signaling to Cell Therapy; Pre-Clinical and Clinical Issues
Volume: 7 Issue: 2
Author(s): Therese Cronin, Thierry Leveillard and Jose-Alain Sahel
Affiliation:
Keywords: Signaling, photoreceptor, neuroprotection, retinal degeneration, trophic factors, thioredoxin
Abstract: Extracellular signaling molecules have been implicated in the progression of Retinal Degeneration (RD). Gene regulatory events linked to the maintenance of retinal structure and function incorporate signaling cascades that may serve as therapeutic targets for some forms of blindness. This review shall focus on the evidence for non-cell-autonomous mechanisms that affect the pattern of degeneration seen in retinal dystrophies, the types of signals that may influence the course of degeneration and finally with the related prospects for retinal-therapies.
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Cronin Therese, Leveillard Thierry and Sahel Jose-Alain, Retinal Degenerations: From Cell Signaling to Cell Therapy; Pre-Clinical and Clinical Issues, Current Gene Therapy 2007; 7 (2) . https://dx.doi.org/10.2174/156652307780363143
DOI https://dx.doi.org/10.2174/156652307780363143 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
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