Abstract
Recent work is reviewed concerning the synthesis of estrone or estradiol homologues, of interest in diagnostics, drug discovery research etc. The survey is limited to reactions where a carbon atom or a carbon chain becomes directly attached to the steroid ring system. Also conversions of non-estranoid starting materials to substituted estrone/estradiol derivatives are discussed. The organization of the review follows steroid numbering.
Keywords: hydroxymethylated derivative, estrogen derivatives, Barton-McCombie deoxygenation, C-alkylation, Wolff-Kishner reduction
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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