ICAM-1 in Acute Myocardial Infarction: A Potential Therapeutic Target

Title: ICAM-1 in Acute Myocardial Infarction: A Potential Therapeutic Target

Volume: 7 Issue: 2

Author(s): Victoria Benson, Aisling Clare McMahon and Harry Claude Lowe

Affiliation:

Keywords: Acute myocardial infarction, ischaemia, reperfusion, adhesion molecule

Abstract: Current treatments for AMI centre on prompt restoration of epicardial coronary blood flow. Despite improvements, AMI is still associated with significant morbidity and mortality. Novel approaches are therefore keenly sought. Intercellular adhesion molecule-1 (ICAM-1, CD54) is a member of the immunoglobulin superfamily. It is implicated in neutrophil and monocyte-endothelial cell adhesion, processes contributing to myocardial neutrophil infiltration and microvascular coronary slow flow, both viewed as important to the pathophysiologic responses in AMI. ICAM-1 would therefore appear an important potential therapeutic target in this context, and is the subject of this review.

Cite this article as:

Benson Victoria, Clare McMahon Aisling and Claude Lowe Harry, ICAM-1 in Acute Myocardial Infarction: A Potential Therapeutic Target, Current Molecular Medicine 2007; 7 (2) . https://dx.doi.org/10.2174/156652407780059131