Abstract
We describe the case of a young HIV-positive man on effective HAART with excellent viro-immunological control who presented a massive cardiac infarction. Despite the presence of clinical risk factors for cardiovascular disease, the patient had normal arterial carotid IMT values, known to be strong predictors of atherosclerosis and stroke. Interestingly, parameters of T-cell activation (CD8+CD38+) were shown to increase just before the onset of myocardial infarction. As T-cell activation is known to mediate atherosclerosis, the authors suggest that surrogate immunologic markers should be identified to better assess cardiovascular risk in the setting of HIV infection.
Keywords: Atherosclerosis, cardiovascular risk, HAART, immune activation, intima media thickness
Current HIV Research
Title: Sudden Cardiac Death in a Young HIV-Positive Man on Effective Antiretroviral Therapy
Volume: 6 Issue: 6
Author(s): Camilla Tincati, Dario Bauer, Giusi M. Bellistri, Maddalena Casana, Roberto Ranieri, Teresa Bini, Giulia Marchetti and Antonella Arminio Monforte
Affiliation:
Keywords: Atherosclerosis, cardiovascular risk, HAART, immune activation, intima media thickness
Abstract: We describe the case of a young HIV-positive man on effective HAART with excellent viro-immunological control who presented a massive cardiac infarction. Despite the presence of clinical risk factors for cardiovascular disease, the patient had normal arterial carotid IMT values, known to be strong predictors of atherosclerosis and stroke. Interestingly, parameters of T-cell activation (CD8+CD38+) were shown to increase just before the onset of myocardial infarction. As T-cell activation is known to mediate atherosclerosis, the authors suggest that surrogate immunologic markers should be identified to better assess cardiovascular risk in the setting of HIV infection.
Export Options
About this article
Cite this article as:
Tincati Camilla, Bauer Dario, Bellistri M. Giusi, Casana Maddalena, Ranieri Roberto, Bini Teresa, Marchetti Giulia and Monforte Arminio Antonella, Sudden Cardiac Death in a Young HIV-Positive Man on Effective Antiretroviral Therapy, Current HIV Research 2008; 6 (6) . https://dx.doi.org/10.2174/157016208786501517
DOI https://dx.doi.org/10.2174/157016208786501517 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Compounds that Combine Aldose Reductase Inhibitory Activity and Ability to Prevent the Glycation (Glucation and/or Fructation) of Proteins as Putative Pharmacotherapeutic Agents
Drug Design Reviews - Online (Discontinued) Editorial [Hot Topic: Novel Factor Xa-and Thrombin-Inhibitors (Executive Editor: Giuseppe G. Nenci)]
Current Pharmaceutical Design Anti-Inflammatory Treatments for Chronic Diseases: A Review
Inflammation & Allergy - Drug Targets (Discontinued) Polydeoxyribonucleotide (PDRN): A Safe Approach to Induce Therapeutic Angiogenesis in Peripheral Artery Occlusive Disease and in Diabetic Foot Ulcers
Cardiovascular & Hematological Agents in Medicinal Chemistry A SELDI-TOF-MS Study in Lacunar Stroke with Subsequent Haptoglobin Phenotyping
Current Neurovascular Research Impact of Diabetes on Vasculature: Focus on Nervous System
Current Diabetes Reviews New Insights into the Surgical Management of Tetralogy of Fallot: Physiological Fundamentals and Clinical Relevance
Current Pediatric Reviews Preface
Vascular Disease Prevention (Discontinued) Targeting the Mevalonate Pathway for Improved Anticancer Therapy
Current Cancer Drug Targets Meet Our Section Editor
Current Medicinal Chemistry Systems Biology Research into Cardiovascular Disease: Contributions of Lipidomics-based Approaches to Biomarker Discovery
Current Drug Discovery Technologies Diet, Cardiometabolic Factors and Type-2 Diabetes Mellitus: The Role of Genetics
Current Diabetes Reviews SGLT-2 Inhibitors in Type 1 Diabetes Mellitus: A Comprehensive Review of the Literature
Current Clinical Pharmacology AKT Signaling in Regulating Angiogenesis
Current Cancer Drug Targets Subject Index To Volume 12
Current Pharmaceutical Design Role of Heme Oxygenase-1 in Cardiovascular Function
Current Pharmaceutical Design The Role of the Gut Microbiota in Energy Metabolism and Metabolic Disease
Current Pharmaceutical Design Screening Neuroprotective Agents Through 4-hydroxynonenal, Ethanol, High Glucose, Homocysteine, Okadaic Acid, Rotenone, and Oxygen-Glucose Deprivation Induced PC12 Injury Models: A Review
Current Psychopharmacology Genetic Risk Factors in Cerebrovascular Disorders and Cognitive Deterioration
Current Genomics Role of microRNAs in Vascular Remodeling
Current Molecular Medicine