Chemokine Receptors Expression on T Cells and Response to HAART Among Chronic HIV-1-Infected Subjects

Title: Chemokine Receptors Expression on T Cells and Response to HAART Among Chronic HIV-1-Infected Subjects

Volume: 6 Issue: 6

Author(s): Adriana Brito, Paula O. Rigato, Alexandre Almeida, Simone S. Fernandes, Claudio R. Gonsalez, Luiz A.M. Fonseca, Alberto J.S. Duarte and Jorge Casseb

Affiliation:

Keywords: HIV-1, chemokines, co-receptors, CCR5, CXCR4, antiretroviral therapy

Abstract: Chemokines receptors are used by HIV-1 for entry into CD4+ T cells. The β-chemokines are capable of inhibiting HIV replication. This study determined the CCR5 and CXCR4 expression on T cells in HIV-1-infected patients treated with HAART. The successfully treated group (plasma viral load < 400 copies/mL), when compared with the failure group (plasma viral load > 400 copies/mL), had higher median CD4+ T cells count (583 and 245 cells/mm3; respectively, p < 0.0001). The failure patients had higher numbers and intensity of CCR5 and CXCR4-expressing T cells. Successfully treated patients were able to normalize the co-receptors expression-over on T cells. The viremic group showed higher CCR5 expression on CD4+ T cells and lower number of cells; CCR5 expression was normalized in the aviremic group; the naive group showed lower CCR5 expression and higher numbers of CD4 T cells; all groups showed normal CXCR4 expression compared to healthy controls. These findings may have clinical implications, since down-regulation of these co-receptors could be an adjuvant strategy for anti-HIV treatment.

Cite this article as:

Brito Adriana, Rigato O. Paula, Almeida Alexandre, Fernandes S. Simone, Gonsalez R. Claudio, Fonseca A.M. Luiz, Duarte J.S. Alberto and Casseb Jorge, Chemokine Receptors Expression on T Cells and Response to HAART Among Chronic HIV-1-Infected Subjects, Current HIV Research 2008; 6 (6) . https://dx.doi.org/10.2174/157016208786501436