Possibilities of Two-Dimensional Gel Electrophoresis in the Understanding of Human Disease

Title: Possibilities of Two-Dimensional Gel Electrophoresis in the Understanding of Human Disease

Volume: 4 Issue: 4

Author(s): Jose Luis Lopez and Jose Bermudez-Crespo

Affiliation:

Keywords: Proteomics, two-dimensional electrophoresis, biomarker discovery, drug discovery, clinical applications

Abstract: Because of the multifactorial nature of many diseases, two-dimensional electrophoresis is a basic proteomics tool for its ability of simultaneously detecting post-and co-translational modifications, which cannot be predicted from genome sequences. This review describes the central role of proteomics tool, two-dimensional electrophoresis for clinical biomarker discovery, the identification of prognostic and diagnostic markers, their use in monitoring the effects of drug treatments and eventually finding more efficient and safer therapeutics for a wide range of pathologies.

Cite this article as:

Lopez Luis Jose and Bermudez-Crespo Jose, Possibilities of Two-Dimensional Gel Electrophoresis in the Understanding of Human Disease, Current Proteomics 2007; 4 (4) . https://dx.doi.org/10.2174/157016407783221259