Targeting Strategies to Modulate the NF-κB and JNK Signal Transduction Network

Title: Targeting Strategies to Modulate the NF-κB and JNK Signal Transduction Network

Volume: 6 Issue: 1

Author(s): Michael Kracht

Affiliation:

Keywords: chromatin-immunoprecipitation (ChIP), MAP kinase kinase kinases (MAKKK), ATP-competitve inhibitors, c-JUN Docking Sites, tumor necrosis factor

Abstract: The signal transduction pathways leading to activation of Jun-NH2-terminal kinase (JNK) and nuclear factor- κB (NF-κB) are activated by a plethora of extracellular signals. Small molecules have been developed that inhibit the JNK or IκB protein kinases. Additionally, several cell-penetrating peptides have been characterized that disrupt proteinprotein interaction domains within the NF-κB and JNK signalling pathways. Usually NF-κB and JNK are (re)viewed as separate signalling systems. However, emerging evidence suggests that both pathways are interconnected at various levels. In this review, the spatiotemporal control of JNK or NF-κ B activation is discussed in conjunction with cross talk mechanisms and various regulatory feedback loops. A detailed understanding of these mechanisms is important to optimize available strategies to interfere with NF-κB or JNK signalling.

Cite this article as:

Kracht Michael, Targeting Strategies to Modulate the NF-κB and JNK Signal Transduction Network, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2007; 6 (1) . https://dx.doi.org/10.2174/187152307779939705