Immune Modulation of HIV Replication: Relevance to HIV Immuno- and Neuro-Pathogenesis

Title: Immune Modulation of HIV Replication: Relevance to HIV Immuno- and Neuro-Pathogenesis

Volume: 2 Issue: 4

Author(s): Elizabeth Z. Managlia, Deborah Carroll, Andrew Zloza and Lena Al-Harthi

Affiliation:

Keywords: immune reconstitution, cytokine therapy, hiv, neuropathogenesis

Abstract: Much attention has been focused on CD4+ memory / primed T cells and monocytes / macrophages as the predominant targets of HIV infection. Considerable evidence, however, indicates that cell types that are classically not permissive to HIV infection, can be a potent source of productive virus replication in response to immune modulation. This immune modulation can be in the form of cytokine stimulation pre- or postinfection or by activating these “non-conventional” targets. In this review, we will provide evidence for immune modulation of HIV infection with special emphasis on immune modulation of HIV replication in classically non-HIV permissive primary cells of both lymphoid and non-lymphoid origins. We will also examine the impact of HIV infection of these non-conventional targets as they pertain to both HIV immunoand neuro-pathogenesis.

Cite this article as:

Managlia Z. Elizabeth, Carroll Deborah, Zloza Andrew and Al-Harthi Lena, Immune Modulation of HIV Replication: Relevance to HIV Immuno- and Neuro-Pathogenesis, Current HIV Research 2004; 2 (4) . https://dx.doi.org/10.2174/1570162043351020