Combining DNA Damaging Agents and Checkpoint 1 Inhibitors

Title: Combining DNA Damaging Agents and Checkpoint 1 Inhibitors

Volume: 4 Issue: 5

Author(s): Michelle Prudhomme

Affiliation:

Keywords: dna damaging agents, checkpoint 1 inhibitors, g2 checkpoint inhibitor, mitosis

Abstract: During the cell cycle that leads to mitosis, checkpoints are activated in response to DNA damage. The checkpoints control the ability of cells to arrest the cell cycle allowing time to repair the DNA. In more than 50% of cancer cells, the G1 checkpoint is inactive due to mutations of p53. Therefore, the combination of a DNA damaging agent with a G2 checkpoint inhibitor should force selectively cancer cells into a premature and lethal mitosis. This approach which has recently drawn considerable interest is discussed in this paper.

Cite this article as:

Prudhomme Michelle, Combining DNA Damaging Agents and Checkpoint 1 Inhibitors, Current Medicinal Chemistry - Anti-Cancer Agents 2004; 4 (5) . https://dx.doi.org/10.2174/1568011043352795