Abstract
Fresh hepatocytes have been the choice for interspecies comparative drug metabolism studies. Cryopreserved hepatocytes represent a readily available alternative when combined with acceptance limits based on the metabolic turnover of 7-ethoxycoumarin. Results for the ten NCEs examined show that the metabolites formed were strongly correlated in fresh and cryopreserved hepatocytes.
Keywords: Cryopreserved hepatocytes, fresh hepatocytes, comparative metabolism, metabolite profiling, structural identification, radiochemical flow detection
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