Comparison of Paraben Stability in Human and Rat Skin

Title: Comparison of Paraben Stability in Human and Rat Skin

Volume: 1 Issue: 1

Author(s): Heather M. Harville, Richard Voorman and Jeffery J. Prusakiewicz

Affiliation:

Keywords: Paraben, esterase, skin, epidermal drug metabolism

Abstract: Parabens are widely used preservatives in topical products, and are estrogenic in numerous experimental models. The typical cutaneous metabolism model, rat skin, hydrolyzes parabens much faster than human skin. Chronic application and absorption of parabens, combined with low metabolism rates, may lead to prolonged estrogenic effects in the skin.

Cite this article as:

Harville M. Heather, Voorman Richard and Prusakiewicz J. Jeffery, Comparison of Paraben Stability in Human and Rat Skin, Drug Metabolism Letters 2007; 1 (1) . https://dx.doi.org/10.2174/187231207779814300