Efficient Synthesis of 3-Aminoimidazo[1,2-a] Pyridines Using Silica-Supported Perchloric Acid (HClO4-SiO2) as a Novel Heterogenous Catalyst

Azizollah      Habibi; Zahra      Tarameshloo; Shahnaz      Rostamizadeh; Ali      M. Amani

doi:10.2174/157017812800167439

Abstract

One pot three-component reaction of 2-amino pyridines, aldehydes and isocyanides in the presence of silicasupported perchloric acid (HClO4-SiO2), produces 3-aminoimidazo[1,2-a] pyridines in excellent yields. The reaction time is short and work up of reaction is very easy. New compounds were identified by IR, 1H NMR, 13C NMR and Mass spectrum.

Keywords: 3-Aminoimidazo[1,2-a] pyridine, isocyanide, multi-component reaction, silica-supported perchloric acid (HClO4-SiO2), annulanes, calcium, heterocycles, medicinal chemistry, pyrazine, aldehydes

Rights & Permissions Print Cite

Letters in Organic Chemistry

Title: Efficient Synthesis of 3-Aminoimidazo[1,2-a] Pyridines Using Silica-Supported Perchloric Acid (HClO4-SiO2) as a Novel Heterogenous Catalyst

Volume: 9 Issue: 3

Author(s): Azizollah Habibi, Zahra Tarameshloo, Shahnaz Rostamizadeh and Ali M. Amani

Affiliation:

Abstract: One pot three-component reaction of 2-amino pyridines, aldehydes and isocyanides in the presence of silicasupported perchloric acid (HClO4-SiO2), produces 3-aminoimidazo[1,2-a] pyridines in excellent yields. The reaction time is short and work up of reaction is very easy. New compounds were identified by IR, 1H NMR, 13C NMR and Mass spectrum.

Export Options

Export File:

RIS (for EndNote, Reference Manager, ProCite)

BibTeX

Text

Content:

Citation Only

Citation and Abstract

About this article

Cite this article as:

Habibi Azizollah, Tarameshloo Zahra, Rostamizadeh Shahnaz and M. Amani Ali, Efficient Synthesis of 3-Aminoimidazo[1,2-a] Pyridines Using Silica-Supported Perchloric Acid (HClO4-SiO2) as a Novel Heterogenous Catalyst, Letters in Organic Chemistry 2012; 9 (3) . https://dx.doi.org/10.2174/157017812800167439