Abstract
Carbon-carbon bond forming reactions are simple and direct methods for synthesizing the various skeletons and the diverse structures of organic compounds. Even 100 years after the discovery of the Grignard reaction, organomagnesium, organolithium, and organoaluminum remain popular for carbon-carbon bond formation reactions in modern organic chemistry. Moreover, asymmetric alkyl- or aryl-additions to carbonyl compounds with organometal reagents is attractive due to the enantioselective synthesis of chiral secondary alcohols, which sharply contrasts the enantioselective reduction of carbonyl compounds. Herein, we review recent progress in the selective addition to carbonyl compounds with organometal reagents, particularly Li, Mg, and Zn from both a classic viewpoint using metal ate complexes and from a catalytic enantioselective viewpoint using new chiral ligands.
Keywords: arylmagnesates, aldehydes, Allyl-Addition, Chiral auxiliaries, Bifunctional Catalysts, Alkynylation
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Books
Advances in Organic Synthesis
The Synthetic Methods, Structures, and Properties of the Ca-C σ Bond Organocalcium Containing Compounds
Advances in Organic Synthesis
Chemistry of Bipyrazoles: Synthesis and Applications
Advances in Organic Synthesis
Advanced Nanocatalysis for Organic Synthesis and Electroanalysis
Advances in Organic Synthesis
Advances in Organic Synthesis
19