Abstract
This Review reports recent developments in the synthesis of benzo-fused heterocycles through Pd-catalyzed carbon-carbon and carbon-heteroatom bond forming reactions via direct C-H activation. Nitrogen-, oxygen- and sulfur-containing heterocyclic rings can be rapidly assembled starting from precursors with minimal preactivation. Compared to classical coupling reactions (i.e. Suzuki, Stille, Buchwald-Hartwig), these methods provide a more straightforward and economical route to various heterocyclic scaffolds, which is of practical importance considering their role in biology and pharmaceutical industry.
Keywords: Palladium, Homogeneous Catalysis, C-H Activation, Organic Halides, Oxidation, Heterocycles, Cyclization, palladium-catalyzed, C-H bond activation/C-C coupling reactions, cross-coupling, regioselectivity, heteroarenes
Current Organic Synthesis
Title: Heterocycle Synthesis Based on Palladium-Catalyzed C-H Bond Functionalization Methods
Volume: 9 Issue: 1
Author(s): Raffaella Ferraccioli
Affiliation:
Keywords: Palladium, Homogeneous Catalysis, C-H Activation, Organic Halides, Oxidation, Heterocycles, Cyclization, palladium-catalyzed, C-H bond activation/C-C coupling reactions, cross-coupling, regioselectivity, heteroarenes
Abstract: This Review reports recent developments in the synthesis of benzo-fused heterocycles through Pd-catalyzed carbon-carbon and carbon-heteroatom bond forming reactions via direct C-H activation. Nitrogen-, oxygen- and sulfur-containing heterocyclic rings can be rapidly assembled starting from precursors with minimal preactivation. Compared to classical coupling reactions (i.e. Suzuki, Stille, Buchwald-Hartwig), these methods provide a more straightforward and economical route to various heterocyclic scaffolds, which is of practical importance considering their role in biology and pharmaceutical industry.
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Cite this article as:
Ferraccioli Raffaella, Heterocycle Synthesis Based on Palladium-Catalyzed C-H Bond Functionalization Methods, Current Organic Synthesis 2012; 9 (1) . https://dx.doi.org/10.2174/157017912798889224
DOI https://dx.doi.org/10.2174/157017912798889224 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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