Synthesis of Phosphorus Ligands from Zirconium Reagents. A Useful Approach

Title: Synthesis of Phosphorus Ligands from Zirconium Reagents. A Useful Approach

Volume: 11 Issue: 1

Author(s): Maria Zablocka and Jean-Pierre Majoral

Affiliation:

Keywords: substituted phospholane, phosphorus-zirconium salts, Schwartz reagent, metallocene transition complexes, 1,1-diphosphines

Abstract: The use of several zirconium reagents as the Schwartz reagent [Cp2ZrHCl]n, the dimethylzirconocene Cp2ZrMe2, the zirconocene [Cp2Zr], and the diphenylzirconocene Cp2ZrPh2 allows the synthesis of a variety of new linear and cyclic P-C and P-N ligands. 1,1 diphosphines can be prepared from unsaturated monophosphines. A useful methodology involving ring opening reactions permits the preparation of phosphinite-phosphine and bis-phosphinite ligands. N-functionalized imines and β-diimines substituted with phosphino groups are obtained from cyanophosphines or dinitriles. Carbozirconation of chlorophospha-imine leads to the unprecedented P-metalated iminophosphorane which presents a versatile reactivity towards electrophiles and small unsaturated molecules. Constraint three and four phosphorus cycles can be easily isolated using [Cp2M] (M = Zr or Ti). Interactions between benzynezirconocene and unsaturated phosphines afford numerous methods to prepare linear and cyclic phosphorus reagents. Enantiomerically pure iminophosphines can be synthetized from phosphinozirconocene complexes.

Cite this article as:

Zablocka Maria and Majoral Jean-Pierre, Synthesis of Phosphorus Ligands from Zirconium Reagents. A Useful Approach, Current Organic Chemistry 2007; 11 (1) . https://dx.doi.org/10.2174/138527207779316480