Efficient Synthesis of 7-benzyl-5,6,7,8-tetrahydropyrido[4',3':4',5]thieno [2,3-d]pyrimidin-4(3H)-Ones Via Aza-Wittig Reaction

Hong      Chen; Kai      Yan; Ming-Guo      Liu

doi:10.2174/157017811799304250

Abstract

7-benzyl-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(3H)-ones were synthesized by base catalytic reactions of nucleophilic reagents (aliphatic amines, alcohols or phenols) with carbodiimides 4, which were obtained from the aza-Wittig reaction of iminophosphoranes 3 with aromatic isocyanates.

Keywords: Aza-Wittig reaction, carbodiimide, iminophosphorane, thieno[2, 3-d]pyrimidin-4(3H)-one, alkyl, antianxiety, antiarrhythmic, antiprotozoal, benzene

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Letters in Organic Chemistry

Title: Efficient Synthesis of 7-benzyl-5,6,7,8-tetrahydropyrido[4',3':4',5]thieno [2,3-d]pyrimidin-4(3H)-Ones Via Aza-Wittig Reaction

Volume: 8 Issue: 9

Author(s): Hong Chen, Kai Yan and Ming-Guo Liu

Affiliation:

Keywords: Aza-Wittig reaction, carbodiimide, iminophosphorane, thieno[2, 3-d]pyrimidin-4(3H)-one, alkyl, antianxiety, antiarrhythmic, antiprotozoal, benzene

Abstract: 7-benzyl-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(3H)-ones were synthesized by base catalytic reactions of nucleophilic reagents (aliphatic amines, alcohols or phenols) with carbodiimides 4, which were obtained from the aza-Wittig reaction of iminophosphoranes 3 with aromatic isocyanates.

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Chen Hong, Yan Kai and Liu Ming-Guo, Efficient Synthesis of 7-benzyl-5,6,7,8-tetrahydropyrido[4',3':4',5]thieno [2,3-d]pyrimidin-4(3H)-Ones Via Aza-Wittig Reaction, Letters in Organic Chemistry 2011; 8 (9) . https://dx.doi.org/10.2174/157017811799304250