Multiple Functions of Rad9 for Preserving Genomic Integrity

Title: Multiple Functions of Rad9 for Preserving Genomic Integrity

Volume: 7 Issue: 8

Author(s): Kazuhiro Ishikawa, Hideshi Ishii, Toshiyuki Saito and Keiichi Ichimura

Affiliation:

Keywords: DNA damage, replication, checkpoint, cancer

Abstract: DNA-damage checkpoints sense and respond to genomic damage. Human Rad9 (hRad9), an evolutionarily conserved gene with multiple functions for preserving genomic integrity, plays multiple roles in fundamental biological processes, including the regulation of the DNA damage response, cell cycle checkpoint control, DNA repair, apoptosis, transcriptional regulation, exonuclease activity, ribonucleotide synthesis and embryogenesis. This review examines work that provides significant insight into the molecular mechanisms of several individual cellular processes which might be beneficial for developing novel therapeutic approaches to cancerous diseases with genomic instability.

Cite this article as:

Ishikawa Kazuhiro, Ishii Hideshi, Saito Toshiyuki and Ichimura Keiichi, Multiple Functions of Rad9 for Preserving Genomic Integrity, Current Genomics 2006; 7 (8) . https://dx.doi.org/10.2174/138920206779315746