Copper-Catalyzed Direct Amination of Halo(hetero)arenes with Sodium Azide as the Amino Source

S.      Messaoudi; J.-D.      Brion; M.      Alami

doi:10.2174/157019311797440236

Abstract

In the synthesis of primary (hetero)aryl amines through copper-catalysis, the ammonia surrogates or aqueous ammonia nucleophilic partners can be replaced by sodium azide. Recent efforts in copper-mediated transformation of (hetero)aryl halides to (hetero) aryl amines using azide anion as the amino source are discussed in these highlights.

Keywords: Amination, Anilines, Aminoheterocycles, Sodium azide, copper, copper-catalysis

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Mini-Reviews in Organic Chemistry

Title: Copper-Catalyzed Direct Amination of Halo(hetero)arenes with Sodium Azide as the Amino Source

Volume: 8 Issue: 4

Author(s): S. Messaoudi, J.-D. Brion and M. Alami

Affiliation:

Keywords: Amination, Anilines, Aminoheterocycles, Sodium azide, copper, copper-catalysis

Abstract: In the synthesis of primary (hetero)aryl amines through copper-catalysis, the ammonia surrogates or aqueous ammonia nucleophilic partners can be replaced by sodium azide. Recent efforts in copper-mediated transformation of (hetero)aryl halides to (hetero) aryl amines using azide anion as the amino source are discussed in these highlights.

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Messaoudi S., Brion J.-D. and Alami M., Copper-Catalyzed Direct Amination of Halo(hetero)arenes with Sodium Azide as the Amino Source, Mini-Reviews in Organic Chemistry 2011; 8 (4) . https://dx.doi.org/10.2174/157019311797440236