Mild and Efficient Iodine-Catalyzed Direct Substitution of Hydroxy Group of Alcohols with C- and N-Nucleophiles

Title: Mild and Efficient Iodine-Catalyzed Direct Substitution of Hydroxy Group of Alcohols with C- and N-Nucleophiles

Volume: 8 Issue: 1

Author(s): Zhe Liu, Dong Wang and Yongjun Chen

Affiliation:

Keywords: Allylation, Bond formation, C-, N-nucleophiles, Green chemistry, Iodine, Isomerization, Propargylation, Substitution

Abstract: A mild and efficient iodine-catalyzed direct substitution of hydroxy group of allylic, progargylic and other alcohols with various C- and N-nucleophiles was described in this contribution. C-C and C-N bond formations could be readily achieved by non-metallic and green catalysis for various compounds. This facilitates access to possible transformations of a broad scope of substrates into bioactive and pharmaceutically important building blocks.

Cite this article as:

Liu Zhe, Wang Dong and Chen Yongjun, Mild and Efficient Iodine-Catalyzed Direct Substitution of Hydroxy Group of Alcohols with C- and N-Nucleophiles, Letters in Organic Chemistry 2011; 8 (1) . https://dx.doi.org/10.2174/157017811794557787