A DFT Explanation of the Reactivity and Regioselectivity of the Diels- Alder Reactions Between 2,3,4,4a-Tetrahydroquinoline and some Electron-Deficient Dienophiles

Title: A DFT Explanation of the Reactivity and Regioselectivity of the Diels- Alder Reactions Between 2,3,4,4a-Tetrahydroquinoline and some Electron-Deficient Dienophiles

Volume: 8 Issue: 2

Author(s): Rachid Jalal, M. Jose Aurell and M'hamed Esseffar

Affiliation:

Keywords: DFT, Diels-Alder reactions, 2,3,4,4a-tetrahydroquinoline, regioselectivity, global and local reactivity parameters, stereoisomers, ethylene, acetylene, nucleophilicity, electrophiles

Abstract: Reactivity and regioselectivity for the experimentally studied Diels-Alder reactions between the 2,3,4,4a-tetrahydroquinoline 1 and some electrophilically activated dienophiles 2 [E.V. Nikitina, V.N. Khrustalev, D.G. Grudinin, F.A.A. Toze, V.V. Kouznetsov, F.I. Zubkov, Tetrahedron, 2010, 66, 15, 2889] have been analysed within the framework of reactivity parameters derived from DFT in global and local sense at B3LYP/6-31G(d) level of theory.

Cite this article as:

Jalal Rachid, Jose Aurell M. and Esseffar M'hamed, A DFT Explanation of the Reactivity and Regioselectivity of the Diels- Alder Reactions Between 2,3,4,4a-Tetrahydroquinoline and some Electron-Deficient Dienophiles, Letters in Organic Chemistry 2011; 8 (2) . https://dx.doi.org/10.2174/157017811794697430