A Differential Scanning Calorimetry Study of the Effects and Interactions of Antimicrobial Peptide LS3 on Phosphatidylethanolamine Bilayers

Title: A Differential Scanning Calorimetry Study of the Effects and Interactions of Antimicrobial Peptide LS3 on Phosphatidylethanolamine Bilayers

Volume: 17 Issue: 11

Author(s): Farid Sa'adedin and Jeremy P. Bradshaw

Affiliation:

Keywords: Antimicrobial peptide, amphipathic helix, DSC, LS3, phosphatidylethanolamine, phase transition, Antimicrobial, amphipathic, phase, (LSSLLSL)3, bilayer, (DSC), crystallography, DOPE, (MLVs), EDTA, TH, PE bilayers, DPOPE

Abstract: Differential Scanning Calorimetry studies of a synthetic peptide revealed the peptide decreased the temperature of the lamellar-hexagonal phase transition of cis-trans mixtures of phosphatidylethanolamine. The transition enthalpy varied significantly with lipid composition. The findings are discussed with reference to peptide saturation on the bilayer surface, bilayer thinning and peptide orientation.

Cite this article as:

Sa'adedin Farid and P. Bradshaw Jeremy, A Differential Scanning Calorimetry Study of the Effects and Interactions of Antimicrobial Peptide LS3 on Phosphatidylethanolamine Bilayers, Protein & Peptide Letters 2010; 17 (11) . https://dx.doi.org/10.2174/0929866511009011345

DOI https://dx.doi.org/10.2174/0929866511009011345	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305