Recent Advances in the Medicinal Chemistry of Novel Erythromycin- Derivatized Antibiotics

Title: Recent Advances in the Medicinal Chemistry of Novel Erythromycin- Derivatized Antibiotics

Volume: 10 Issue: 14

Author(s): Lu Ying and Datong Tang

Affiliation:

Keywords: Macrolide antibiotics, erythromycin, SAR, antibacterial

Abstract: Development of novel erythromycin-based antibiotics has been one of the most studied topics in the past three decades. Such tremendous efforts have generated a number of beneficiary drugs such as clarithromycin, azithromycin and telithromycin. However, widespread application of antibiotics in clinical practice has triggered an increasing emergence of bacterial resistance. Therefore, discovery of novel macrolide antibiotics to suppress the resistance is urgent for human healthcare. This review focuses on advances in the area since 2004.

Cite this article as:

Ying Lu and Tang Datong, Recent Advances in the Medicinal Chemistry of Novel Erythromycin- Derivatized Antibiotics, Current Topics in Medicinal Chemistry 2010; 10 (14) . https://dx.doi.org/10.2174/156802610792232042