One-Pot Synthesis of Enaminones Using Golds Reagent

Title: One-Pot Synthesis of Enaminones Using Golds Reagent

Volume: 7 Issue: 6

Author(s): Tamer S. Saleh, Mohamed A. Al-Omar and Hatem A. Abdel-Aziz

Affiliation:

Keywords: Enaminone, cyanuric chloride, gold's reagent, DMF-DMA, Ketone

Abstract: Enaminones were efficiently prepared via modification for Gupton method, which depends on carrying out the latter procedure in one step reaction, avoiding the isolation of [3-(dimethylamino)-2-azaprop-2-en-1- ylidene]dimethylammonium chloride (Golds reagent) (5) which is prepared in situ from cyanuric chloride (4) then it reacts successfully with ketone 1a-j to produce the enaminones 3a-j in suitable yields. The modified method overcomes the drawbacks of the known methods for preparation of enaminones.

Cite this article as:

S. Saleh Tamer, A. Al-Omar Mohamed and A. Abdel-Aziz Hatem, One-Pot Synthesis of Enaminones Using Golds Reagent, Letters in Organic Chemistry 2010; 7 (6) . https://dx.doi.org/10.2174/157017810791824793