Polycationic Nanoparticles as Nonviral Vectors Employed for Gene Therapy in vivo

Title: Polycationic Nanoparticles as Nonviral Vectors Employed for Gene Therapy in vivo

Volume: 10 Issue: 2

Author(s): Jinfeng Xing, Liandong Deng, Shutao Guo, Anjie Dong and Xing-Jie Liang

Affiliation:

Keywords: Gene therapy, polycation, nanoparticles, non-viral vectors, transfection efficiency, PEGylation, gene delivery, circulation time

Abstract: Currently, polycationic nanoparticles (polycation) as nonviral vectors are promising to overcome the defects of traditional viral vectors. This review focuses on the recent progress and challenges to improve the transfection efficacy and circulation time of polyplexes (complexes between polycation and pDNA or oligonucleotides such as siRNA ) in vivo.

Cite this article as:

Xing Jinfeng, Deng Liandong, Guo Shutao, Dong Anjie and Liang Xing-Jie, Polycationic Nanoparticles as Nonviral Vectors Employed for Gene Therapy in vivo, Mini-Reviews in Medicinal Chemistry 2010; 10 (2) . https://dx.doi.org/10.2174/138955710791185127