Knocking Down Gene Expression with Dendritic Vectors

M.      Ravina; P.      Paolicelli; B.      Seijo; A.      Sanchez

doi:10.2174/138955710791112569

Abstract

The aim of this review is to provide the reader with an overview on the potential of dendritic polymers in the antisense delivery technology. Special emphasis has been placed on the different types of dendritic structures that have been reported and the modifications performed to increase their efficacy and safety. Therefore the advances made in their chemistry and how it has been adapted to meet the specific requirements of the antisense delivery technology are reviewed and discussed.

Keywords: Dendrimers, dendriplexes, gene silencing, antisense therapy, antisense delivery, siRNA delivery, gene therapy, knocking down