A Multi-Scale Parameterization Approach of Peptides for Quantitative Sequence-Activity Models

Weihuan      Niu; Qingyou      Xia; Guizhao      Liang

doi:10.2174/092986610791112738

Abstract

A multi-scale parameterization approach, factor analysis scales of generalized amino acid information combined with auto cross covariance, was used to develop quantitative sequence-activity models of peptides using support vector machines. The results demonstrated that this approach could well characterize sequence features of the peptides studied.

Keywords: Factor analysis scales of generalized amino acid information (FASGAI), auto cross covariance (ACC), FASGAI-ACC, quantitative sequence-activity model (QSAM), support vector machines (SVM)

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