Benzoxazine and Benzodioxine as Indole Isosteres in Indolocarbazoles Series: Synthesis and Biological Evaluation

Nathalie      Ayerbe; Sylvain      Routier; Isabelle      Gillaizeau; Sebastien      Tardy; Gerard      Coudert

doi:10.2174/157017810790796291

Abstract

New series of structure based on original benzodioxine and benzoxazine heterocycles were prepared leading to potential anticancer lead compounds. In this paper, we described a convenient approach via a Diels-Alder cycloaddition in order to efficiently provide three new indole isosteres in indolocarbazoles series. Their first cytotoxic evaluation was also reported.

Keywords: Benzodioxine, benzoxazine, indolocarbazole, cytotoxicity

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Letters in Organic Chemistry

Title: Benzoxazine and Benzodioxine as Indole Isosteres in Indolocarbazoles Series: Synthesis and Biological Evaluation

Volume: 7 Issue: 2

Author(s): Nathalie Ayerbe, Sylvain Routier, Isabelle Gillaizeau, Sebastien Tardy and Gerard Coudert

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Keywords: Benzodioxine, benzoxazine, indolocarbazole, cytotoxicity

Abstract: New series of structure based on original benzodioxine and benzoxazine heterocycles were prepared leading to potential anticancer lead compounds. In this paper, we described a convenient approach via a Diels-Alder cycloaddition in order to efficiently provide three new indole isosteres in indolocarbazoles series. Their first cytotoxic evaluation was also reported.

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Ayerbe Nathalie, Routier Sylvain, Gillaizeau Isabelle, Tardy Sebastien and Coudert Gerard, Benzoxazine and Benzodioxine as Indole Isosteres in Indolocarbazoles Series: Synthesis and Biological Evaluation, Letters in Organic Chemistry 2010; 7 (2) . https://dx.doi.org/10.2174/157017810790796291