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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Cationic Micellar-Catalyzed Hydrolysis of Pesticide Fenitrothion Using α-Nucleophiles

Author(s): Shuchi Tiwari, Kallol K. Ghosh, Jan Marek and Kamil Kuca

Volume 7, Issue 3, 2010

Page: [194 - 199] Pages: 6

DOI: 10.2174/157018010790596650

Price: $65

Abstract

Comparative nucleophilicity of various α-nucleophiles like butane 2, 3-dione monoxime (BDMO), pralidoxime (2-PAM) and benzohydroxamic acid (BHA) towards hydrolysis of pesticide fenitrothion has been measured in the presence of various cationic surfactants at 27°C. It is shown that butane 2, 3-dione monoxime exhibits more reactivity for the degradation of fenitrothion. Effect of alkyl chain length, nucleophile concentration and pH on the rate of reaction of fenitrothion has also been studied.

Keywords: Fenitrothion, Cationic surfactant, Hydrolysis, α-Nucleophiles


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