A New Practical Synthesis of Linezolid: An Antibacterial Drug

Ganta   Madhusudhan   Reddy; Akula      Ramulu; Padi   Pratap   Reddy

doi:10.2174/157017810790533878

Abstract

A novel and practical asymmetric synthesis of (S)-N-[[3-(3-fluoro-4-morpholinyl phenyl)-2-oxo-5-oxazolidinyl] methyl]acetamide has been developed by a new approach without recourse to chromatography and it is employed for the synthesis of Linezolid. This involves the reaction of (R)-epichlorohydrin with N-arylcarbamates and subsequent regioselective epoxide ring opening of resulted intermediate by sodium azide.

Keywords: Linezolid, antibacterial drug, asymmetric synthesis, regioselective epoxide ring opening, one pot synthesis

« Previous Next »

Rights & Permissions Print Cite

Letters in Organic Chemistry

Title: A New Practical Synthesis of Linezolid: An Antibacterial Drug

Volume: 7 Issue: 1

Author(s): Ganta Madhusudhan Reddy, Akula Ramulu and Padi Pratap Reddy

Affiliation:

Keywords: Linezolid, antibacterial drug, asymmetric synthesis, regioselective epoxide ring opening, one pot synthesis

Abstract: A novel and practical asymmetric synthesis of (S)-N-[[3-(3-fluoro-4-morpholinyl phenyl)-2-oxo-5-oxazolidinyl] methyl]acetamide has been developed by a new approach without recourse to chromatography and it is employed for the synthesis of Linezolid. This involves the reaction of (R)-epichlorohydrin with N-arylcarbamates and subsequent regioselective epoxide ring opening of resulted intermediate by sodium azide.

Export Options

Export File:

RIS (for EndNote, Reference Manager, ProCite)

BibTeX

Text

Content:

Citation Only

Citation and Abstract

About this article

Cite this article as:

Reddy Madhusudhan Ganta, Ramulu Akula and Reddy Pratap Padi, A New Practical Synthesis of Linezolid: An Antibacterial Drug, Letters in Organic Chemistry 2010; 7 (1) . https://dx.doi.org/10.2174/157017810790533878