Novel Derivatives of 1,3-Dimethyl-5-methylenebarbituric Acid

Kamal      Sweidan; Qutaiba      Abu-Salem; Ahmed      Al-Sheikh; Ghassan   Abu   Sheikha

doi:10.2174/157017809790442934

Abstract

The ability of the pyridinium adduct of 1,3-dimethyl-5-methylenebarbituric acid (2) to undergo nucleophilic substitution reaction has been examined. Various types of nucleophiles, including cyanide, barbiturate, sulfide anions and 1,2-bis(diphenylphosphino)ethane substitute the pyridinium fragment in 2 leading to synthesis of new organic derivatives.

Keywords: 1,3-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione (1,3-dimethylbarbituric acid), zwitterionic pyridinium adduct, nucleophilic substitution reaction

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Letters in Organic Chemistry

Title: Novel Derivatives of 1,3-Dimethyl-5-methylenebarbituric Acid

Volume: 6 Issue: 8

Author(s): Kamal Sweidan, Qutaiba Abu-Salem, Ahmed Al-Sheikh and Ghassan Abu Sheikha

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Keywords: 1,3-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione (1,3-dimethylbarbituric acid), zwitterionic pyridinium adduct, nucleophilic substitution reaction

Abstract: The ability of the pyridinium adduct of 1,3-dimethyl-5-methylenebarbituric acid (2) to undergo nucleophilic substitution reaction has been examined. Various types of nucleophiles, including cyanide, barbiturate, sulfide anions and 1,2-bis(diphenylphosphino)ethane substitute the pyridinium fragment in 2 leading to synthesis of new organic derivatives.

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Sweidan Kamal, Abu-Salem Qutaiba, Al-Sheikh Ahmed and Sheikha Abu Ghassan, Novel Derivatives of 1,3-Dimethyl-5-methylenebarbituric Acid, Letters in Organic Chemistry 2009; 6 (8) . https://dx.doi.org/10.2174/157017809790442934