α-N-Heterocyclic Thiosemicarbazone Derivatives as Potential Antitumor Agents: A Structure-Activity Relationships Approach

Title: α-N-Heterocyclic Thiosemicarbazone Derivatives as Potential Antitumor Agents: A Structure-Activity Relationships Approach

Volume: 9 Issue: 12

Author(s): Ana I. Matesanz and Pilar Souza

Affiliation:

Keywords: α-N-heterocyclic thiosemicarbazone, bis(thiosemicarbazone), ribonucleotide reductase inhibitors, antitumour agents, metal complexes, structure-activity relationships

Abstract: α-N-Heterocyclic thiosemicarbazones, (N)-TSCs, are potent inhibitors of ribonucleotide reductase (RR). This enzyme plays a critical role in DNA synthesis and repair, and is a well-recognized target for cancer chemotherapeutic agents. In this review the structural features of (N)-TSCs, required for maximum antitumour activity have been explored. Special attention is given to the mechanisms of action and structure-activity relationships.

Cite this article as:

Matesanz I. Ana and Souza Pilar, α-N-Heterocyclic Thiosemicarbazone Derivatives as Potential Antitumor Agents: A Structure-Activity Relationships Approach, Mini-Reviews in Medicinal Chemistry 2009; 9 (12) . https://dx.doi.org/10.2174/138955709789957422