A Practical Approach Towards Synthesis of Octahydroquinazolinone Derivatives in Water

Hai-Xia      Lin; Xiao-Zhen      Xie; Xiao-Hong      Wang; Bin      He

doi:10.2174/157017809789869555

Abstract

A simple, efficient and green procedure has been developed for the synthesis of octahydroquinazolinone derivatives by Biginelli-type three-component cyclocondensation reactions of cyclic β-diketones, aldehydes and (thio)urea with p-TsOH catalysis in water.

Keywords: Octahydroquinazolinone, biginelli reaction, cyclic β-diketones, p-toluenesulfonic acid, synthesis, catalysis

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Letters in Organic Chemistry

Title: A Practical Approach Towards Synthesis of Octahydroquinazolinone Derivatives in Water

Volume: 6 Issue: 7

Author(s): Hai-Xia Lin, Xiao-Zhen Xie, Xiao-Hong Wang and Bin He

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Keywords: Octahydroquinazolinone, biginelli reaction, cyclic β-diketones, p-toluenesulfonic acid, synthesis, catalysis

Abstract: A simple, efficient and green procedure has been developed for the synthesis of octahydroquinazolinone derivatives by Biginelli-type three-component cyclocondensation reactions of cyclic β-diketones, aldehydes and (thio)urea with p-TsOH catalysis in water.

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Lin Hai-Xia, Xie Xiao-Zhen, Wang Xiao-Hong and He Bin, A Practical Approach Towards Synthesis of Octahydroquinazolinone Derivatives in Water, Letters in Organic Chemistry 2009; 6 (7) . https://dx.doi.org/10.2174/157017809789869555