Synthesis and Biological Activity of New Triazole Compounds

Title: Synthesis and Biological Activity of New Triazole Compounds

Volume: 7 Issue: 1

Author(s): Hanane Al Bay, Bouchra Quaddouri, Abdelkarim Guaadaoui, Rachid Touzani, Nour-Eddine Benchat, Abdellah Hamal, Mustafa Taleb, Mohammed Bellaoui and Sghir El Kadiri

Affiliation:

Keywords: Synthesis, Antifungal activity, Antibacterial activity, Tridentate ligand, Nitrogen-rich and Triazole

Abstract: Six new N,N-bis(1,2,4-triazol-1-ylmethyl)amines have been prepared in one step by condensation of 1- (hydroxymethyl)triazole with a series of amines. These reactions were carried out in refluxed CH3CN for 4 hours. The products were recuperated with excellent and good yields (75-89.5%). Compounds (3a-f) were screened for their antifungal activity against the budding yeast Saccharomyces cerevisiae and their antibacterial activity against Escherichia coli.

Cite this article as:

Bay Al Hanane, Quaddouri Bouchra, Guaadaoui Abdelkarim, Touzani Rachid, Benchat Nour-Eddine, Hamal Abdellah, Taleb Mustafa, Bellaoui Mohammed and Kadiri El Sghir, Synthesis and Biological Activity of New Triazole Compounds, Letters in Drug Design & Discovery 2010; 7 (1) . https://dx.doi.org/10.2174/157018010789869352

DOI https://dx.doi.org/10.2174/157018010789869352	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X