Crystal Structure of Bucain, a Three-Fingered Toxin from the Venom of the Malayan Krait (Bungarus candidus)

M.   T.   Murakami; R.   M.   Kini; R.   K.   Arni

doi:10.2174/092986609789839304

Abstract

Bucain, a potent neurotoxin isolated from the venom of the Malayan krait (Bungarus candidus), induces paralysis and death. Its crystal structure has been determined at 2.10 A resolution and based on the molecular topology and hydrophobicity profile is structurally classified as a three-fingered α-neurotoxin possessing a positively charged AChR-binding site.

Keywords: Bucain, crystal structure, Bungarus candidus, three-finger α-neurotoxin

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