Developments in the Synthesis of Organometallic Amino Acids and Analogues

Poulami      Jana; Sibaprasad      Maity; Debasish      Haldar

doi:10.2174/157017910791162995

Abstract

Structure and function of synthetic amino acids with side chain metal complexes have particular importance for extending our understanding of organometallic compounds under physiological conditions and mimic protein folding and stabilization. Chemists are now designing biomimetic organo-metallic amino acids that can form both secondary and tertiary structures. An overview of the design and synthesis of non-proteinogenic amino acids containing metal ions in the side chain is discussed.

Keywords: Amino acid analogues, side chain metal complex, synthesis, structure

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Current Organic Synthesis

Title: Developments in the Synthesis of Organometallic Amino Acids and Analogues

Volume: 7 Issue: 3

Author(s): Poulami Jana, Sibaprasad Maity and Debasish Haldar

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Keywords: Amino acid analogues, side chain metal complex, synthesis, structure

Abstract: Structure and function of synthetic amino acids with side chain metal complexes have particular importance for extending our understanding of organometallic compounds under physiological conditions and mimic protein folding and stabilization. Chemists are now designing biomimetic organo-metallic amino acids that can form both secondary and tertiary structures. An overview of the design and synthesis of non-proteinogenic amino acids containing metal ions in the side chain is discussed.

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Jana Poulami, Maity Sibaprasad and Haldar Debasish, Developments in the Synthesis of Organometallic Amino Acids and Analogues, Current Organic Synthesis 2010; 7 (3) . https://dx.doi.org/10.2174/157017910791162995