A New, Efficient Entry to Non-Lipophilic H-Phosphonate Monoesters – Preparation of Anti-HIV Nucleotide Analogues

Joanna      Romanowska; Agnieszka      Szymanska-Michalak; Malgorzata      Pietkiewicz; Michal      Sobkowski; Jerzy      Boryski; Jacek      Stawinski; Adam      Kraszewski

doi:10.2174/157017809789124821

Abstract

Crystalline ammonium (9H-fluoren-9-yl)methyl H-phosphonate was prepared by a new, simple method and it was used as the reagent of choice for the introduction of an H-phosphonate monoester functionality into non-lipophilic anti-HIV nucleoside analogues.

Keywords: H-phosphonates, phosphonylating agents, nucleoside analogues, nucleoside H-phosphonates, protecting groups, β-elimination

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Letters in Organic Chemistry

Title: A New, Efficient Entry to Non-Lipophilic H-Phosphonate Monoesters – Preparation of Anti-HIV Nucleotide Analogues

Volume: 6 Issue: 6

Author(s): Joanna Romanowska, Agnieszka Szymanska-Michalak, Malgorzata Pietkiewicz, Michal Sobkowski, Jerzy Boryski, Jacek Stawinski and Adam Kraszewski

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Keywords: H-phosphonates, phosphonylating agents, nucleoside analogues, nucleoside H-phosphonates, protecting groups, β-elimination

Abstract: Crystalline ammonium (9H-fluoren-9-yl)methyl H-phosphonate was prepared by a new, simple method and it was used as the reagent of choice for the introduction of an H-phosphonate monoester functionality into non-lipophilic anti-HIV nucleoside analogues.

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Romanowska Joanna, Szymanska-Michalak Agnieszka, Pietkiewicz Malgorzata, Sobkowski Michal, Boryski Jerzy, Stawinski Jacek and Kraszewski Adam, A New, Efficient Entry to Non-Lipophilic H-Phosphonate Monoesters – Preparation of Anti-HIV Nucleotide Analogues, Letters in Organic Chemistry 2009; 6 (6) . https://dx.doi.org/10.2174/157017809789124821