Investigation of the Effect of the Ligand/Palladium Ratio on the Catalytic Activity of Reusable Palladium/Phosphine/Ionic Liquid Systems in Aminocarbonylation of 17-iodo-androst-16-ene with Amino Acid Ester Nucleophiles

Eszter      Takacs; Rita      Skoda-Foldes

doi:10.2174/157017809789124867

Abstract

Ionic liquids as solvents were used effectively in palladium catalysed aminocarbonylation of 17-iodo-5α- androst-16-ene (1) with L-amino acid esters. Interestingly, optimal conditions that are essential for the successful reuse of the ionic liquid/catalyst mixture differ greatly from those observed in the similar reaction with simple secondary amines as nucleophiles.

Keywords: Aminocarbonylation, palladium, amino acid esters, ionic liquids, alkenyl iodide

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Letters in Organic Chemistry

Title: Investigation of the Effect of the Ligand/Palladium Ratio on the Catalytic Activity of Reusable Palladium/Phosphine/Ionic Liquid Systems in Aminocarbonylation of 17-iodo-androst-16-ene with Amino Acid Ester Nucleophiles

Volume: 6 Issue: 6

Author(s): Eszter Takacs and Rita Skoda-Foldes

Affiliation:

Keywords: Aminocarbonylation, palladium, amino acid esters, ionic liquids, alkenyl iodide

Abstract: Ionic liquids as solvents were used effectively in palladium catalysed aminocarbonylation of 17-iodo-5α- androst-16-ene (1) with L-amino acid esters. Interestingly, optimal conditions that are essential for the successful reuse of the ionic liquid/catalyst mixture differ greatly from those observed in the similar reaction with simple secondary amines as nucleophiles.

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Takacs Eszter and Skoda-Foldes Rita, Investigation of the Effect of the Ligand/Palladium Ratio on the Catalytic Activity of Reusable Palladium/Phosphine/Ionic Liquid Systems in Aminocarbonylation of 17-iodo-androst-16-ene with Amino Acid Ester Nucleophiles, Letters in Organic Chemistry 2009; 6 (6) . https://dx.doi.org/10.2174/157017809789124867