Recent Developments in Thrombin-Activatable Fibrinolysis Inhibitor Research

Title: Recent Developments in Thrombin-Activatable Fibrinolysis Inhibitor Research

Volume: 9 Issue: 10

Author(s): Pauline F. Marx, Chantal J.N. Verkleij, Mercedes Valls Seron and Joost C.M. Meijers

Affiliation:

Keywords: TAFI, carboxypeptidase B, carboxypeptidase U, carboxypeptidase R, fibrinolysis, inflammation

Abstract: Thrombin-activatable fibrinolysis inhibitor (TAFI) provides an important molecular link between the coagulation and fibrinolytic systems. In this review, recent major advances in TAFI research, including the elucidation of crystal structures, the development of small inhibitors and the role of TAFI in systems other than hemostasis, are described and discussed.

Cite this article as:

Marx F. Pauline, Verkleij J.N. Chantal, Seron Valls Mercedes and Meijers C.M. Joost, Recent Developments in Thrombin-Activatable Fibrinolysis Inhibitor Research, Mini-Reviews in Medicinal Chemistry 2009; 9 (10) . https://dx.doi.org/10.2174/138955709789055216