Control of the Regioselectivity in Palladium(0)-Catalyzed Allylic Alkylation

Stephanie      Norsikian; Chih-Wei      Chang

doi:10.2174/157017909788921880

Abstract

Palladium(0)-catalyzed allylation of soft nucleophiles is a powerful synthetic methodology for the construction of carboncarbon or carbon-heteroatom bonds. The possibility of controlling the regioselectivity is one of the most interesting aspects of this chemistry. In this review, the different factors that can affect the regiochemistry of the nucleophilic attack will be discussed.

Keywords: Palladium, allylic substitution, regioselectivity, soft nucleophiles, ligands, steric effects

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Current Organic Synthesis

Title: Control of the Regioselectivity in Palladium(0)-Catalyzed Allylic Alkylation

Volume: 6 Issue: 3

Author(s): Stephanie Norsikian and Chih-Wei Chang

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Keywords: Palladium, allylic substitution, regioselectivity, soft nucleophiles, ligands, steric effects

Abstract: Palladium(0)-catalyzed allylation of soft nucleophiles is a powerful synthetic methodology for the construction of carboncarbon or carbon-heteroatom bonds. The possibility of controlling the regioselectivity is one of the most interesting aspects of this chemistry. In this review, the different factors that can affect the regiochemistry of the nucleophilic attack will be discussed.

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Norsikian Stephanie and Chang Chih-Wei, Control of the Regioselectivity in Palladium(0)-Catalyzed Allylic Alkylation, Current Organic Synthesis 2009; 6 (3) . https://dx.doi.org/10.2174/157017909788921880