Novel Detection System for Plant Protein Production of Pharmaceuticals and Impact on Conformational Diseases

Kerstin      A. Nagel; Bernd      Kastenholz; Frank      Gilmer; Ulrich      Schurr; Achim      Walter

doi:10.2174/092986610791190282

Abstract

State-of-the-art biochemistry methods in combination with an automated phenotyping method demonstrate the high potential of transgenic tobacco plants in producing properly-folded therapeutic proteins for the treatment of protein-misfolding diseases (e.g., Alzheimers disease). This molecular farming approach led to highest protein production of hydroponically- grown tobacco compared to other growth substrates generally used in plant cultivation.

Keywords: Protein folding, Alzheimer's disease, molecular farming, PMPs, value-added biochemicals, methodologial strategy

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