Rapid Synthesis of Taxifolione and Taxifolial D, Two Metabolites from the Marine Alga Caulerpa taxifolia

Fabien      Fecourt; Cedric      Carlier; Patrick      Pale

doi:10.2174/157017809787003179

Abstract

The synthesis of two natural products - Taxifolione and Taxifolial D – isolated from the marine alga Caulerpa taxifolia invading the Mediterranean Sea was performed. Coupling reactions allowed for a rapid synthesis. The surprising Z configuration of Taxifolial D was confirmed after synthesis and comparison of each synthetic stereoisomer.

Keywords: Terpenoids, enynes, cross-coupling, antitumor agents

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Letters in Organic Chemistry

Title: Rapid Synthesis of Taxifolione and Taxifolial D, Two Metabolites from the Marine Alga Caulerpa taxifolia

Volume: 6 Issue: 1

Author(s): Fabien Fecourt, Cedric Carlier and Patrick Pale

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Keywords: Terpenoids, enynes, cross-coupling, antitumor agents

Abstract: The synthesis of two natural products - Taxifolione and Taxifolial D – isolated from the marine alga Caulerpa taxifolia invading the Mediterranean Sea was performed. Coupling reactions allowed for a rapid synthesis. The surprising Z configuration of Taxifolial D was confirmed after synthesis and comparison of each synthetic stereoisomer.

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Fecourt Fabien, Carlier Cedric and Pale Patrick, Rapid Synthesis of Taxifolione and Taxifolial D, Two Metabolites from the Marine Alga Caulerpa taxifolia, Letters in Organic Chemistry 2009; 6 (1) . https://dx.doi.org/10.2174/157017809787003179