A Molecular Guidance System Based Upon Target Genes, Nuclear Receptors and Ligands Applied to Drug Discovery and Prediction of Toxicity

Title: A Molecular Guidance System Based Upon Target Genes, Nuclear Receptors and Ligands Applied to Drug Discovery and Prediction of Toxicity

Volume: 8 Issue: 12

Author(s): Virendra B. Mahesh, Neil Sidell, Douglas E. Ewing, Edwin D. Bransome Jr. and Lawrence B. Hendry

Affiliation:

Keywords: Nuclear receptors, intercalators, DNA unwinding, steroid hormones, hormone response elements, computer modeling, transcription, drug design

Abstract: A molecular guidance system useful in drug design is described in which nuclear receptors position ligands in intercalation sites in responsive genes. Evidence is based upon positions of agonists in receptors and the transcriptional activity of a designed estrogen that is 3 times more potent than the steroid hormone estradiol.

Cite this article as:

Mahesh B. Virendra, Sidell Neil, Ewing E. Douglas, Bransome Jr. D. Edwin and Hendry B. Lawrence, A Molecular Guidance System Based Upon Target Genes, Nuclear Receptors and Ligands Applied to Drug Discovery and Prediction of Toxicity, Mini-Reviews in Medicinal Chemistry 2008; 8 (12) . https://dx.doi.org/10.2174/138955708786140972