Novel Microwave-Assisted One-Pot Synthesis of Heterocycle Phosphor Esters and Cyclic Oxophospholes with Antibiotic Activity

Title: Novel Microwave-Assisted One-Pot Synthesis of Heterocycle Phosphor Esters and Cyclic Oxophospholes with Antibiotic Activity

Volume: 5 Issue: 7

Author(s): Wafaa M. Abdou and Abeer A. Shaddy

Affiliation:

Keywords: α, β-Unsaturated carbonitriles, Phosphonyl carbanions, Fused heterocycle phosphonates, Cyclic oxophospholes

Abstract: Reactions of 5,6-di-(2`-furyl)-3-oxo-2,3-dihydropyridazin-4-carbonitrile (1) with Wittig-Horner reagents were investigated under microwave irradiation, and the effect of basic catalysis. The methodology afforded moderate to high yields of fused heterocycles bearing a phosphonate ester and / or phosphor-containing fused heterocycles. Bioassay results showed that the antibiotic activity of the new synthesized phosphorus compounds is significantly high when compared to available Streptomycin and Mycostatin (standard).

Cite this article as:

Abdou M. Wafaa and Shaddy A. Abeer, Novel Microwave-Assisted One-Pot Synthesis of Heterocycle Phosphor Esters and Cyclic Oxophospholes with Antibiotic Activity, Letters in Organic Chemistry 2008; 5 (7) . https://dx.doi.org/10.2174/157017808785982220