96-Well Plate Surface Tension Measurements for Fast Determination of Drug Solubility

Title: 96-Well Plate Surface Tension Measurements for Fast Determination of Drug Solubility

Volume: 5 Issue: 7

Author(s): Tiina Heikkila, Leena Peltonen, Saila Taskinen, Timo Laaksonen and Jouni Hirvonen

Affiliation:

Keywords: Solubility, Surface tension, Ibuprofen, Indomethacin, High throughput screening (HTS), 96-well plate

Abstract: Surface tension based microtensiometric method for HTS (high throughput screening) of drug solubility properties is presented. Method was tested by determining physiologically relevant parameters on the solubility of ibuprofen and indomethacin. Linear correlation was found with equilibrium solubility. According to this study, microtensiometry is a promising technique for HTS solubility testing.

Cite this article as:

Heikkila Tiina, Peltonen Leena, Taskinen Saila, Laaksonen Timo and Hirvonen Jouni, 96-Well Plate Surface Tension Measurements for Fast Determination of Drug Solubility, Letters in Drug Design & Discovery 2008; 5 (7) . https://dx.doi.org/10.2174/157018008785909840

DOI https://dx.doi.org/10.2174/157018008785909840	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X