Octanol Water Partition Coefficient Determination for Model Steroids Using an HPLC Method

Title: Octanol Water Partition Coefficient Determination for Model Steroids Using an HPLC Method

Volume: 5 Issue: 6

Author(s): Sara Zargar Shoshtari, Jingyuan Wen and Raid. G. Alany

Affiliation:

Keywords: Partition coefficient, Reversed phased liquid chromatography, Chromatographic Hydrophobicity Index (CHI), Lipophilicity

Abstract: Applicability of HPLC based models for calculating partition coefficient (logP) of steroids was investigated. Retention time was used to calculate retention factor (logK), isocratic (CHIi) and gradient (CHIg) Chromatography Hydrophobicity Index. CHIi was shown to be an accurate logP predictor for selected steroids and as such offer an alternative to the shake flask method.

Cite this article as:

Shoshtari Zargar Sara, Wen Jingyuan and Alany G. Raid., Octanol Water Partition Coefficient Determination for Model Steroids Using an HPLC Method, Letters in Drug Design & Discovery 2008; 5 (6) . https://dx.doi.org/10.2174/157018008785777333

DOI https://dx.doi.org/10.2174/157018008785777333	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X