Abstract
In recent years, medicinal chemists have begun to realize that dendrimers may be a keystone in the future of medicine. The field of oncology will soon be revolutionized by novel strategies for diagnosis and therapy employing dendrimer-based nanodevices. In the near future, cancer diagnosis via MRI will be improved by the incorporation of dendrimers as advanced contrast agents. Novel dendrimer-based contrast agents can not only be targeted specifically to cancer cells but may also incorporate a cytotoxic function to induce apoptosis on said cells as well. Dendrimers are being applied to a variety of cancer therapies to improve the safety and effectiveness of many common therapeutics. Investigations into the applicability of dendrimers in photodynamic therapy, boron neutron capture therapy, and gene transfection are also being undertaken. This review will cover the fundamentals of cutting-edge research utilizing dendrimers for cancer diagnosis and therapy. An objective review of these new technologies will detail how dendrimerbased nanodevices are advantageous over conventional medicine.
Keywords: PAMAM dendrimer, drug delivery, cancer diagnosis, cancer therapy, chemotherapy, photodynamic therapy, MRI, apoptosis
Current Topics in Medicinal Chemistry
Title: Current Dendrimer Applications in Cancer Diagnosis and Therapy
Volume: 8 Issue: 14
Author(s): Istvan J. Majoros, Christopher R. Williams and James R. Baker Jr.
Affiliation:
Keywords: PAMAM dendrimer, drug delivery, cancer diagnosis, cancer therapy, chemotherapy, photodynamic therapy, MRI, apoptosis
Abstract: In recent years, medicinal chemists have begun to realize that dendrimers may be a keystone in the future of medicine. The field of oncology will soon be revolutionized by novel strategies for diagnosis and therapy employing dendrimer-based nanodevices. In the near future, cancer diagnosis via MRI will be improved by the incorporation of dendrimers as advanced contrast agents. Novel dendrimer-based contrast agents can not only be targeted specifically to cancer cells but may also incorporate a cytotoxic function to induce apoptosis on said cells as well. Dendrimers are being applied to a variety of cancer therapies to improve the safety and effectiveness of many common therapeutics. Investigations into the applicability of dendrimers in photodynamic therapy, boron neutron capture therapy, and gene transfection are also being undertaken. This review will cover the fundamentals of cutting-edge research utilizing dendrimers for cancer diagnosis and therapy. An objective review of these new technologies will detail how dendrimerbased nanodevices are advantageous over conventional medicine.
Export Options
About this article
Cite this article as:
Majoros J. Istvan, Williams R. Christopher and Baker Jr. R. James, Current Dendrimer Applications in Cancer Diagnosis and Therapy, Current Topics in Medicinal Chemistry 2008; 8 (14) . https://dx.doi.org/10.2174/156802608785849049
DOI https://dx.doi.org/10.2174/156802608785849049 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Colchicine in Neurosurgery
Current Pharmaceutical Design Bicycloheptylamine-Doxorubicin Conjugate: Synthesis and Anticancer Activities in σ2 Receptor-Expressing Cell Lines
Medicinal Chemistry Dysregulation of Neurotrophic and Haematopoietic Growth Factors in Alzheimer’s Disease: From Pathophysiology to Novel Treatment Strategies
Current Alzheimer Research Polyethyleneimine-Based Nanocarriers for Gene Delivery
Current Pharmaceutical Design The Blood Brain Barrier, Mechanisms of Cerebral Edema, and the Use of Anti-Inflammatory and other Anti-Edema Agents in Neuro-Oncology
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Towards the Molecular Foundations of Glutamatergic-targeted Antidepressants
Current Neuropharmacology Membrane Targeted Chemotherapy with Hybrid Liposomes for Tumor Cells Leading to Apoptosis
Current Pharmaceutical Design The Potency of Refined Mouse Models: Implications for Clinical Trials
Current Cancer Therapy Reviews MDM2 Increases Drug Resistance in Cancer Cells by Inducing EMT Independent of p53
Current Medicinal Chemistry Membrane Transporters in Physiological Barriers of Pharmacological Importance
Current Pharmaceutical Design Meet Our Editorial Board Member
CNS & Neurological Disorders - Drug Targets Targeting the Akt Kinase to Modulate Survival, Invasiveness and Drug Resistance of Cancer Cells
Current Medicinal Chemistry Polyunsaturated Fatty Acids and their Metabolites in Neural Development and Implications for Psychiatric Disorders
Current Psychopharmacology DNA Methylation: A Possible Target for Current and Future Studies on Cancer?
Epigenetic Diagnosis & Therapy (Discontinued) Metabolic Dysfunction in Alzheimers Disease and Related Neurodegenerative Disorders
Current Alzheimer Research Targeting EGFR in Pancreatic Cancer Treatment
Current Drug Targets In Vitro Evidence for Competitive TSPO Binding of the Imaging Biomarker Candidates Vinpocetine and Two Iodinated DAA1106 Analogues in Post Mortem Autoradiography Experiments on Whole Hemisphere Human Brain Slices
Current Radiopharmaceuticals Brain Proton Magnetic Resonance Spectroscopy: A Review of Main Metabolites and its Clinical Applications in Gliomas
Current Molecular Imaging (Discontinued) Inhibitors of the Hedgehog Signal Transduction Pathway
Current Cancer Therapy Reviews Human Neural Stem and Progenitor Cells: In Vitro and In Vivo Properties, and Potential for Gene Therapy and Cell Replacement in the CNS
Current Gene Therapy