From Cochlear Cell Death Pathways To New Pharmacological Therapies

Jing      Wang; Jean-Luc      Puel

doi:10.2174/138955708785740599

Abstract

Ototoxic drugs, intense sound or age-related hearing loss recruit most of the apoptotic pathways, but also several additional enzymatic pathways which eventually result in cell death. Here, we discuss therapeutic strategies based on the inhibition of regulators or executors of apoptotic cell death pathways and on the use of antioxidants.

Keywords: Apoptosis, necrosis, cell death pathway, cochlea, therapeutic strategies, ototoxic drugs, intense sound, age-related hearing loss